Vitamin C Evidence for Treating
COVID-19 and other Viral Infections
by Magnus P. F. Rasmussen
Acknowledgement - this article has been
produced by the Orthomolecular Medicine
News Service and the mentioned author
and remains their property
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Orthomolecular Medicine News Service, Apr 23, 2020
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List of References:
1. Robert F. Cathcart, M.D, VITAMIN C, TITRATING TO BOWEL TOLERANCE, ANASCORBEMIA, AND ACUTE INDUCED SCURVY, Medical hypotheses, 1981, 7:1359-1376, Vitamin C Foundation.
Link URL: https://vitamincfoundation.org/www.orthomed.com/titrate.htm
2. Sebastian J. Padayatty et al., Vitamin C: Intravenous use by complementary and alternative medicine practitioners and adverse effects, PloS One, 2010; 5(7): e11414 (Epub 2010 Jul 7), doi: 10.1371/journal.pone.0011414
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898816/
3. High-Dose Vitamin C (PDQ(r))-Health Professional Version, NIH - National Cancer Institute, Adverse Effects section, Cancer.gov.
Link URL: https://www.cancer.gov/about-cancer/treatment/cam/hp/vitamin-c-pdq#_18
4. Markos G. Kashiouris et al.,The Emerging Role of Vitamin C as a Treatment for Sepsis, Nutrients, 2020 Feb; 12(2): 292 (Epub 2020 January 22), doi: 10.3390/nu12020292
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070236/
5. Melissa Prier et al., No Reported Renal Stones with Intravenous Vitamin C Administration: A Prospective Case Series Study, Antioxidants (Basel), 2018 May; 7(5): 68 (Epub 2018 May 21), doi: 10.3390/antiox7050068
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981254/
6. The Riordan IVC Protocol for Adjunctive Cancer Care Intravenous Ascorbate as a Chemotherapeutic and Biological Response Modifying Agent, Ron Hunninghake et al., Riordan Clinic Research Institute, 2014.
Link URL: https://riordanclinic.org/wp-content/uploads/2014/11/Riordan_IVC_Protocol.pdf
7. Hemochromatosis and vitamin C, Andrew W. Saul, DoctorYourself.com.
Link URL: http://www.doctoryourself.com/hemochrom.html
8. Sebastian J. Padayatty et al., Vitamin C Pharmacokinetics: Implications for Oral and Intravenous use, Annals of Internal Medicine, 2004;140(7):533-537, doi:10.7326/0003-4819-140-7-200404060-00010Link URL:
Link URL: https://annals.org/aim/fullarticle/717329/vitamin-c-pharmacokinetics-implications-oral-intravenous-use
9. Unexpected Early Response in Oral Bioavailability of Ascorbic Acid, Owen Fonorow, Townsend Letter, TownsendLetter.com, March 13, 2020.
Link URL: https://www.townsendletter.com/article/online-unexpected-oral-vitamin-c-response/
10. Exposing the truth about liposomal nutrients, Dr. Thomas Levy, PeakEnergy.com, April 11, 2014.
Link URL: https://www.peakenergy.com/articles/nh20140411/Exposing-the-truth-about-liposomal-nutrients/
11. Shanghai Expert Group on Clinical Treatment of New Coronavirus Diseases. Expert Consensus on Comprehensive Treatment of Coronavirus Diseases in Shanghai 2019 [J / OL], Chinese Journal of Infectious Diseases, 2020,38 (2020-03-01) , doi: 10.3760 / cma.j.issn.1000-6680.2020.0016. [Pre-published online]
Link URL: http://rs.yiigle.com/yufabiao/1183266.htm
12. Shanghai Expert Consensus on Covid-19 treatment, Dr. Cheng, Cheng Integrative Health Center Blog, Drwlc.com, March 21, 2020.
Link URL: https://www.drwlc.com/blog/2020/03/21/shanghai-expert-consensus-on-covid-19-treatment/
13. Intravenous Ascorbic Acid (IVAA) for COVID-19 Supportive Treatment in Hospitalized COVID-19 Patients (Based on use in China and US settings), Dr. Paul S. Anderson, Isom.ca, March 24, 2020.
Link URL: https://isom.ca/wp-content/uploads/2020/03/IVAA-COVID19-Hospital-Use-Anderson-03.24.2020.pdf
14. Role of Ascorbic Acid in Covid 19 Management, Dr Yuen Chuen Fong Raymond, DoctorYourself.com.
Link URL: http://www.doctoryourself.com/role%20of%20AA%20in%20covid%2019.pdf
15. IVC Protocol, Riordan Clinic, RiordanClinic.org.
Link URL: https://riordanclinic.org/research-study/vitamin-c-research-ivc-protocol/
16. Levy TE (2017) A Guide to the Optimal Administration of Vitamin C. Appendix C in "Hidden Epidemic," MedFox Publishing. ISBN-13: 978-0983772873
Link URL: https://d2taktuuo4oqx.cloudfront.net/2019/imm19/bonus/purchase/Thomas-Levy-Guide-To-The-Optimal-Administration-of-Vitamin-C.pdf
17. Medical Information/COVID Care Protocol, EVMS Medical Group, Eastern Virginia Medical School, EVMS.edu.
Link URL: https://www.evms.edu/covid-19/medical_information_resources/#d.en.140202
18. Rationale for Vitamin C Treatment of COVID-19 and Other Viruses, Orthomolecular Medicine News Service Editorial Review Board, Orthomolecular Medicine News Service, Orthomolecular.org, April 3, 2020.
Link URL: http://orthomolecular.org/resources/omns/v16n21.shtml
19. Preparation of Sodium Ascorbate for IV and IM Use, Robert F. Cathcart III, M.D, Edited 2011 by Owen Fonorow, Vitamin C Foundation, VitaminCFoundation.org.
Link URL: https://vitamincfoundation.org/pdfs/civprep.pdf
20. Cathcart's Instructions on the Preparation of Vitamin C for I.V. Use, vitamincfoundation, February 2, 2011, YouTube.com.
Link URL: https://www.youtube.com/watch?v=Zgi-7xPrCAg
21. Alpha A. Fowler III et al., Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure - The CITRIS-ALI Randomized Clinical Trial, Journal of the American Medical Association (JAMA), 2019;322(13):1261-1270 (Epub 2019 October 1), doi:10.1001/jama.2019.11825
Link URL: https://jamanetwork.com/journals/jama/fullarticle/2752063
22. Vitamin C for Sepsis and Severe ARDS, JAMA Network, YouTube, October 28, 2019.
Link URL: https://www.youtube.com/watch?v=-3_aYNT1KNA
23. Alpha A. Fowler et al., Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis, Journal of Translational Medicine, 2014; 12: 32 (Epub 2014 January 31), doi: 10.1186/1479-5876-12-32
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937164/
24. Mohadeseh H. Zabet et al., Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock, Journal of Research in Pharmacy Practice, 2016 Apr-Jun: 5(2): 94-100, doi: 10.4103/2279-042X.179569
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843590/
25. Paul E. Marik et al., Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study, Chest, 2017 Jun;151(6):1229-1238 (Epub December 6, 2016), doi: 10.1016/j.chest.2016.11.036
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/27940189
26. Eric Wald et al., Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock, American Journal of Respiratory and Critical Care Medicine, 2020 April 1, Volume 201, Issue 7 (Epub January 9, 2020), doi: 10.1164/rccm.201908-1543LE
Link URL: https://www.atsjournals.org/doi/10.1164/rccm.201908-1543LE
27. Vitamin C-B1-Steroid Combo Linked to Lower Septic Shock Mortality in Kids, Ann & Robert H. Lurie Children's Hospital of Chicago, LurieChildrens.org, January 21, 2020.
Link URL: https://www.luriechildrens.org/en/news-stories/vitamin-c-b1-steroid-combo-linked-to-lower-septic-shock-mortality-in-kids/
28. Tomoko Fujii et al., Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock - The VITAMINS Randomized Clinical Trial, Journal of the American Medical Association (JAMA), 2020;323(5):423-431 (Epub 2020 January 17), doi:10.1001/jama.2019.22176
Link URL: https://jamanetwork.com/journals/jama/article-abstract/2759414
29. VITAMINS Trial: Vitamin C and Thiamine for Sepsis and Septic Shock, JAMA Network, YouTube, January 17, 2020.
Link URL: https://www.youtube.com/watch?v=sF2ktY00dqs
30. Anitra C. Carr et al., Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes, Critical Care, 2017 Dec 11;21(1):300, doi: 10.1186/s13054-017-1891-y
Link URL: https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1891-y
31. Tae K. Kim et al., Vitamin C supplementation reduces the odds of developing a common cold in Republic of Korea Army recruits: randomised controlled trial, BMJ Military Health, 2020 Mar 5. pii: bmjmilitary-2019-001384 (Epub ahead of print), doi: 10.1136/bmjmilitary-2019-001384
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/32139409
32. H. Clay Gorton and Kelly Jarvis, The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections, Journal of Manipulative and Physiological Therapeutics, 1999 Oct;22(8):530-3, DOI: 10.1016/s0161-4754(99)70005-9
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=10543583
33. Clare Hunt et al., The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections, International Journal for Vitamin and Nutrition Research, 1994;64(3):212-9., PMID: 7814237
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=1994+hunt+c+vitamin+c
34. Imran M. Khan et al., Efficacy of Vitamin C in Reducing Duration of Severe Pneumonia in Children, Journal Of Rawalpindi Medical College (JRMC), 2014;18(1):55-57, at Journalrmc.com.
Link URL: https://www.journalrmc.com/index.php/JRMC/article/view/381
35. Imran M. Khan et al., Efficacy of Vitamin C in Reducing Duration of Severe Pneumonia in Children, Journal Of Rawalpindi Medical College (JRMC), 2014;18(1):55-57, at Journalrmc.com.
Link URL: https://www.journalrmc.com/index.php/JRMC/article/view/381/290
36. Ren Shiguang et al., Observation on the therapeutic effect of intravenous large dose of vitamin C on infants and young children with viral pneumonia, Hebei Medicine, 1978,4:1-3., at China National Knowledge Infrastructure, Cnki.com.cn.
Link URL: http://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ197804000.htm
37. Ren Shiguang et al., Observation on the therapeutic effect of intravenous large dose of vitamin C on infants and young children with viral pneumonia, Hebei Medicine, 1978,4:1-3., at Hebei Medical Journal, Hbyz.chinajournal.net.cn.
Link URL: http://hbyz.chinajournal.net.cn/WKD/WebPublication/paperDigest.aspx?paperID=c9874a37-7d84-4d9b-8eeb-07bc95a55d7f
38. Harri Hemilä and Elizabeth Chalker, Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis, Journal of Intensive Care, 2020; 8: 15 (Epub 2020 February 7), doi: 10.1186/s40560-020-0432-y
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006137/
39. Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis, Harri Hemilä and Elizabeth Chalker, Nutrients, 2019 Apr; 11(4): 708 (Epub 2019 March 27), doi: 10.3390/nu11040708.
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521194/
40. Harri Hemilä and Elizabeth Chalker, Vitamin C for preventing and treating the common cold, Cochrane Database of Systematic reviews, 2013 Jan 31;(1):CD000980, doi: 10.1002/14651858.CD000980.pub4.
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/23440782/
41. Vitamin C for preventing and treating the common cold, Hari Hemilä and Elizabeth Chalker, Cochrane, Cochrane.org, January 31, 2013.
Link URL: https://www.cochrane.org/CD000980/ARI_vitamin-c-for-preventing-and-treating-the-common-cold
42. Harri Hemilä, Vitamin C and Infections, Nutrients, 2017 Apr; 9(4): 339 (Epub 2017 March 29), doi: 10.3390/nu9040339
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409678/
43. Anitra C. Carr and Silvia Maggini, Vitamin C and Immune Function, Nutrients, 2017 Nov; 9(11): 1211 (Epub 2017 November 3), doi: 10.3390/nu9111211
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/
44. Harri Hemilä and Robert M. Douglas, Vitamin C and acute respiratory infections, International Journal of Tuberculosis and Lung Disease, 1999 Sep;3(9):756-61, PMID: 10488881
Link URL: https://www.researchgate.net/publication/12811097_Vitamin_C_and_acute_respiratory_infections
45. Sebastian J. Padayatty and Mark Levine, Vitamin C physiology: the known and the unknown and Goldilocks, Oral Diseases, 2016 Sep; 22(6): 463-493 (Epub 2016 April 14), doi: 10.1111/odi.12446
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959991/
46. iSepsis - Vitamin C, Hydrocortisone and Thiamine - The "Metabolic Resuscitation Protocol", Paul Marik, EMCrit.org - iSepsis Project (EMCrit), July, 16 2017.
Link URL: https://emcrit.org/isepsis/isepsis-vitamin-c-hydrocortisone-thiamine-metabolic-resuscitation-protocol/
47. Paul E. Marik and Michael H. Hooper, Doctor-your septic patients have scurvy!, Critical Care, 2018 Jan 29;22(1):23, doi: 10.1186/s13054-018-1950-z
Link URL: https://ccforum.biomedcentral.com/articles/10.1186/s13054-018-1950-z
48. Salim Surani and Munish Sharma, Revisiting the Role of Vitamin C in Sepsis. Is it a Forlorn Hope or is there Still Dearth of data?, The Open Respiratory Medicine Journal, Bentham Open, Benthamopen.com, 2019 Dec 31;13:55-57, doi: 10.2174/1874306401913010055
Link URL: https://benthamopen.com/FULLTEXT/TORMJ-13-55
49. Clinical Guide to the Use of Vitamin C, Lendon H. Smith. M.D, AscorbateWeb, 1988.
Link URL: https://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
50. Frederick R. Klenner, M.D, The Treatment of Poliomyelitis and Other Virus Diseases with Vitamin C, Southern Medicine & Surgery, Volume 111, Number 7, July, 1949, pp. 209-214.
Link URL: https://www.seanet.com/~alexs/ascorbate/194x/klenner-fr-southern_med_surg-1949-v111-n7-p209.htm
51. Frederick R. Klenner, M.D, Observations On the Dose and Administration of Ascorbic Acid When Employed Beyond the Range Of A Vitamin In Human Pathology, Journal of Applied Nutrition, Vol. 23, No's 3 & 4, Winter 1971.
Link URL: http://www.doctoryourself.com/klennerpaper.html
52. Publications by Robert F. Cathcart, Orthomed.com (Cathcart's website), Vitamin C Foundation, VitaminCFoundation.org.
Link URL: https://vitamincfoundation.org/www.orthomed.com/publications1.html
53. The Clinical Impact of Vitamin C: My Personal Experience as a Physician, Thomas E. Levy, Orthomolecular Medicine News Service, Orthomolecular.org, September 3, 2014.
Link URL: http://www.orthomolecular.org/resources/omns/v10n14.shtml
54. Richard Z. Cheng, Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?, Medicine in Drug Discovery, 2020 March 26, doi: 10.1016/j.medidd.2020.100028
Link URL: https://www.sciencedirect.com/science/article/pii/S2590098620300154
55. Safe and Effective Modalities For COVID-19 That Can Not Be 'Proven'", Dr. Charles Chun-En Hsu, M.D, Afternoon Health, April 1, 2020.
Link URL: https://www.afternoonhealth.com/2020/04/01/safe-effective-modalities-for-covid-19-that-can-never-be-proven/
56. Successful High-Dose Vitamin C Treatment of Patients with Serious and Critical COVID-19 Infection, Richard Cheng PhD, Orthomolecular Medicine News Service, March 18, 2020.
Link URL: http://www.orthomolecular.org/resources/omns/v16n18.shtml
57. How to Get Intravenous Vitamin C Given to a Hospitalized Patient: A Checklist, Andrew W. Saul, DoctorYourself.com, 2019.
Link URL: http://www.doctoryourself.com/strategies.html
58. Colds, Flus and COVID-19: Can Supplements Help?, Prof Kylie O'Brien PhD and Prof Ian Brighthope, Australasian College Of Nutritional And Environmental Medicine (ACNEM), ACNEM.org, 2020.Link URL:
Link URL: https://www.acnem.org/sites/default/files/pdf/2020/Key%20Supplements%20for%20Protecting%20Against%20&%20Treating%20Colds,%20Flus%20&%20COVID-19.pdf
59. Colds, Flus and COVID-19: Can Supplements Help?, Prof Kylie O'Brien PhD and Prof Ian Brighthope, Australasian College Of Nutritional And Environmental Medicine (ACNEM), ACNEM.org, 2020. - This is a placeholder since the page is currently restricted.
Link URL: https://www.acnem.org/videos/Supplements-Flus-COVID-19
60. STOP ARDS NOW WITH ASCORBIC ACID, Doris Loh, Evolutamente.it, March 28, 2020.
Link URL: https://www.evolutamente.it/stop-ards-now-with-ascorbic-acid/
61. MITOCHONDRIA & THE CORONAVIRUS - THE VITAMIN C CONNECTION (PART 3), Doris Loh, Evolutamente.it, February 1, 2020.
Link URL: https://www.evolutamente.it/mitochondria-the-coronavirus-the-vitamin-c-connection-part-3/
62. COVID-19, FURINS & HYPOXIA - THE VITAMIN C CONNECTION, Doris Loh, Evolutamente.it, February 29, 2020.
Link URL: https://www.evolutamente.it/covid-19-furins-cancer-a-tale-of-vitamin-c-hif/
63. COVID-19 MUTATIONS, VACCINES & NITRIC OXIDE - THE VITAMIN C CONNECTION, Doris Loh, Evolutamente.it, March 7, 2020.
Link URL: https://www.evolutamente.it/covid-19-mutations-vaccines-nitric-oxide-the-vitamin-c-connection/
64. COVID-19, PNEUMONIA & INFLAMMASOMES - THE MELATONIN CONNECTION, Doris Loh, Evolutamente.it, March 14, 2020.
Link URL: https://www.evolutamente.it/covid-19-pneumonia-inflammasomes-the-melatonin-connection/
65. COVID-19, ARDS & CELL-FREE HEMOGLOBIN - THE ASCORBIC ACID CONNECTION, Doris Loh, Evolutamente.it, March 24, 2020.
Link URL: https://www.evolutamente.it/covid-19-ards-cell-free-hemoglobin-the-ascorbic-acid-connection/
66. Vitamin C the Miracle Swine Flu Cure - 60 minutes Living Proof, LivLong, YouTube, January 8, 2019.
Link URL: https://www.youtube.com/watch?v=Au-mp6RZjCQ&feature=youtu.be
67. NZ Farmer Beats Swine Flu with Vitamin C, Food Matters, YouTube, November 9, 2010.
Link URL: https://www.youtube.com/watch?v=GApXBaZuw14&feature=youtu.be
68. Alpha A. Fowler et al., Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome, World Journal of Critical Care Medicine, 2017 Feb 4; 6(1): 85-90 (Epub 2017 February 4), doi: 10.5492/wjccm.v6.i1.85
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295174/
69. Covid-19 and Vitamin D Information, Dr Gareth Davies (PhD), Dr Joanna Byers (MBChB), Dr Attila R Garami (MD, PhD), Google Docs.
Link URL: https://docs.google.com/document/d/1jffdZOSuIA64L_Eur8qyCQ12T7NXrHSKPxtMe134C0Y/edit
70. Former CDC Chief. Dr. Tom Frieden: Coronavirus infection risk may be reduced by Vitamin D, Op-ed by Tom Frieden, M.D, Fox News, March 2020.
Link URL: https://www.foxnews.com/opinion/former-cdc-chief-tom-frieden-coronavirus-risk-may-be-reduced-with-vitamin-d
71. Harri Hemilä and Pekka Louhiala, Vitamin C may affect lung infections, Journal of the Royal Society of Medicine, 2007 Nov; 100(11): 495-498, doi: 10.1258/jrsm.100.11.495
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099400/
72. Harri Hemilä and Pekka Louhiala, Vitamin C for preventing and treating pneumonia, Cochrane Database Systematic Review, 2013 Aug 8;(8):CD005532, doi: 10.1002/14651858.CD005532.pub3.
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/23925826/
73. Won-Young Kim et al., Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study, Journal of Critical Care, 2018 Oct;47:211-218 (Epub 2018 July 5). doi: 10.1016/j.jcrc.2018.07.004
Link URL: https://www.sciencedirect.com/science/article/pii/S0883944118307780
74. Yin Li and Guoping Li., Is Vitamin C Beneficial to Patients with CAP, Current Infectious Disease Reports, 2016 Aug;18(8):24. doi: 10.1007/s11908-016-0530-0.
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/27363830
75. Jaykaran Charan et al., Vitamin D for prevention of respiratory tract infections: A systematic review and meta-analysis, Journal of Pharmacology & Pharmacotherapeutics, 2012 Oct-Dec; 3(4): 300-303, doi: 10.4103/0976-500X.103685
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543548/
76. Pramath Kakodkar et al., A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19), Cureus, Cureus 12(4): e7560, 2020 April 6, doi: 10.7759/cureus.7560
Link URL: https://www.cureus.com/articles/29670-a-comprehensive-literature-review-on-the-clinical-presentation-and-management-of-the-pandemic-coronavirus-disease-2019-covid-19
77. Case for Vitamin C for COVID-19, Patrick Halford, PatrickHolford.com, Mar 29, 2020.
Link URL: https://www.patrickholford.com/blog/case-vitamin-c-covid-19
78. Rui Zhang et al., COVID-19: Melatonin as a potential adjuvant treatment, Life Sciences, 2020 June 1; 250: 117583 (Epub 2020 March 23), doi: 10.1016/j.lfs.2020.117583
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583/
79. COVID-19, ARDS & CYTOKINE STORMS - THE RECYCLING OF ASCORBIC ACID BY MACROPHAGES, NEUTROPHILS AND LYMPHOCYTES, Doris Loh, Evolutamente.it, April 5, 2020.
Link URL: https://www.evolutamente.it/covid-19-ards-cytokine-storms-the-recycling-of-ascorbic-acid-by-macrophages-neutrophils-and-lymphocytes/
80. Michael A. Matthay et al., Treatment of severe acute distress syndrome from COVID-19, The Lancet Respiratory Medicine, 2020 March 20, doi:
Link URL: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30127-2/fulltext
81. Coronavirus Coverup - Vitamin C Dramatic Help against Infection in China, South Korea - Why Aren't We Told, Mara Leverkuhn, Medium.com, March 17, 2020.
Link URL: https://medium.com/@MaraLeverkuhn/vitamin-c-dramatically-helps-against-coronavirus-infection-romanian-biophysicist-2341dc7e7a38
82. BRIGHTHOPE CORONAVIRUS SHARE GENERAL, Dr. Ian Brighthope, available at Dropbox.com.
Link URL: https://www.dropbox.com/sh/grh9r2srqqpqtzw/AAC5rEoVb4XTP-uViXZkrJFWa?dl=0
83. Ping Chang et al., Combined treatment with hydrocortisone, vitamin C, and thiamine for sepsis and septic shock (HYVCTTSSS): A randomized controlled clinical trial, Chest, 2020 Mar 31. pii: S0012-3692(20)30552-3, doi: 10.1016/j.chest.2020.02.065.
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/32243943
84. Overview of planned or ongoing studies of drugs for the treatment of COVID-19, Danish Medicines Agency, Laegemiddelstyrelsen.dk.
Link URL: https://laegemiddelstyrelsen.dk/da/nyheder/temaer/ny-coronavirus-covid-19/~/media/5B83D25935DF43A38FF823E24604AC36.ashx
85. ZhiYong Peng, Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia, Date of registration: February 11, 2020, ClinicalTrials.gov.
Link URL: https://clinicaltrials.gov/ct2/show/NCT04264533
86. Jun Lin, A randomized, open, controlled trial for diammonium glycyrrhizinate enteric-coated capsules combined with vitamin C tablets in the treatment of common novel coronavirus pneumonia (COVID-19) in the basic of clinical standard antiviral treatment to evaluate the safety and efficiency, Date of registration: February 12, 2020, Chinese Clinical Trial Registry, Chictr.org.cn.
Link URL: http://www.chictr.org.cn/showprojen.aspx?proj=49131
87. Gao Defeng, An observational study of high-dose Vitamin C in the treatment of severe and critical patients with novel coronavirus pneumonia (COVID-19), Date of registration: February 17, 2020, Chinese Clinical Trial Registry, Chictr.org.cn.
Link URL: http://www.chictr.org.cn/showprojen.aspx?proj=49633
88. Gao Defeng, A randomized controlled trial for high-dose Vitamin C in the treatment of severe and critical novel coronavirus pneumonia (COVID-19) patients, Date of registration: February 24, 2020, Chinese Clinical Trial Registry, Chictr.org.cn.Link URL:
Link URL: http://www.chictr.org.cn/showprojen.aspx?proj=50002
89. Salvatore Corrao, Use of Ascorbic Acid in Patients With COVID 19, Date of registration: March 26, 2020, ClinicalTrials.gov.
Link URL: https://www.clinicaltrials.gov/ct2/show/NCT04323514
90. Markos. G. Kashiouris and Alpha A. Fowler, Early Infusion of Vitamin C for Treatment of Novel COVID-19 Acute Lung Injury (EVICT-CORONA-ALI), Date of registration: April 14, 2020, ClinicalTrials.gov.
Link URL: https://clinicaltrials.gov/ct2/show/NCT04344184
91. Three Intravenous Vitamin C Research Studies Approved for Treating COVID-19, Andrew W. Saul, February 21, 2020, Orthomolecular.org.
Link URL: http://www.orthomolecular.org/resources/omns/v16n12.shtml
92. Adnan Erol, High-dose intravenous vitamin C treatment for COVID-19, preprint (not yet peer reviewed), 2020 February, doi: 10.31219/osf.io/p7ex8.
Link URL: https://www.researchgate.net/publication/339511104_High-dose_intravenous_vitamin_C_treatment_for_COVID-19
93. Mihnea Zdrenghea et al., Vitamin D modulation of innate immune responses to respiratory viral infections, Reviews in Medical Virology, 2017 Jan;27(1) (Epub 2016 Oct 7), doi: 10.1002/rmv.1909
Link URL: https://www.researchgate.net/publication/308946447_Vitamin_D_modulation_of_innate_immune_responses_to_respiratory_viral_infections
94. Xiaojiao Zheng, et al., TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein, Journal of Virology, May 1, 2017; 91(9): e00088-17, (Epub: 2017 April 13), doi: 10.1128/JVI.00088-17
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391446/
95. Nidhi Kaushik, et al., Zinc: A Potential Antiviral Against Hepatitis E Virus Infection?, DNA and Cell Biology, 2018 Jul;37(7):593-599 (Epub 2018 June 13), doi: 10.1089/dna.2018.4175
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/29897788
96. S. A. Read et al., The antiviral role of zinc and metallothioneins in hepatitis C infection, Journal of Viral Hepatitis, 2018 May;25(5):491-501, doi: 10.1111/jvh.12845
Link URL: https://www.ncbi.nlm.nih.gov/pubmed/29239069
97. Aartjan J. W. te Velthuis et al., Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture, PLoS Pathogens, 2010 Nov; 6(11): e1001176 (Epub: 2010 Nov 4), doi: 10.1371/journal.ppat.1001176
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/
98. Jing Xue, et al., Chloroquine is a Zinc Ionophore, PLoS One, 2014; 9(10): e109180 (Epub: 2014 Oct 1), doi: 10.1371/journal.pone.0109180
Link URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/
99. Husam Dabbagh-Bazarbachi et al., Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model, Journal of Agricultural and Food Chemistry, 2014, 62, 32, 8085-8093, doi.org/10.1021/jf5014633
Link URL: https://pubs.acs.org/doi/10.1021/jf5014633
100. Martin Scholtz and Roland Derwan, Does Zinc Supplementation Enhance the Clinical Efficacy of Chloroquine/Hydroxychloroquine to Win Todays Battle Against COVID-19?, preprints (not peer yet reviewed) 2020 April 8, doi: 10.20944/preprints202004.0124.v1
101. Published Research and Articles on Vitamin C as a Consideration for Pneumonia, Lung Infections, and the Novel Coronavirus (SARS-CoV-2/COVID-19), Graham Player, PhD et al., March 22, 2020, Orthomolecular Medicine News Service, Orthomolecular.org.