Vitamin C levels in patients with

SARS-CoV-2-associated acute

respiratory distress syndrome

  • Luis Chiscano-Camón, 

  • Juan Carlos Ruiz-Rodriguez, 

  • Adolf Ruiz-Sanmartin, 

  • Oriol Roca & 

  • Ricard Ferrer 


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Vitamin C is an antioxidant with anti-inflammatory

and immune-supportive properties. Its levels are

decreased in patients with sepsis-related acute

respiratory distress syndrome (ARDS). Moreover,

a significant number of patients with severe acute

respiratory syndrome coronavirus-2 (SARS-CoV-2)

disease developed ARDS [1]. Therefore, we

hypothesized that ARDS coronavirus disease 2019

(COVID-19) patients may present vitamin C deficiency.


Our study has several limitations mainly related with

the fact that it is a unicentric study with small sample

size and blood sample was obtained in different days

of their course in the ICU.


In conclusion, in our cohort of patients with COVID-19-

associated ARDS, the levels of vitamin C are extremely

low. Despite the limited generalization of these results,

we think these findings might stimulate clinicians to measure

vitamin C levels in COVID-19 patients to describe the

real impact of this alteration.